Methanol → HCID 13853731, compound

HRID 979305Notes

Reaction equation

HRID 979305 reaction equation
[CH3:1][O:2][C:3]1[C:16]2[C:7]([S:8][C:9]3[C:14]([N:15]=2)=[CH:13][CH:12]=[C:11]([O:17][CH3:18])[CH:10]=3)=[CH:6][C:5](=[O:19])[CH:4]=1.[Br:20]Br.CO>C(O)(=O)C>[Br:20][C:6]1[C:5](=[O:19])[CH:4]=[C:3]([O:2][CH3:1])[C:16]2[C:7]=1[S:8][C:9]1[C:14](=[CH:13][CH:12]=[C:11]([O:17][CH3:18])[CH:10]=1)[N:15]=2

Participants

5

Reactant 3

HCID 887MethanolHCID 24408BromineHCID 12199928HCID 12199928, compound

Product 1

HCID 13853731HCID 13853731, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent2×

Procedure

To a suspension of 1,7-dimethoxy-3H-phenothiazin-3-one (300 mg) in acetic acid (9 ml) was added a 0.63M solution of Br2 in acetic acid (1.92 ml). After 15 minutes, methanol was added and the solid filtered, washed with ether and air dried to afford the title compound (353 mg), m.p. 267°-270° C. (dec).

Workup

  1. filtrationthe solid filtered
  2. washwashed with ether and air
  3. customdried

Sources & evidence

ORD record
ord-933d288bd42b4593a7a4458eb5a2bf74
Source dataset
uspto-grants-1987_05
Patent number
US04667032

Reaction notes

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