反应详情

To a stirred solution of 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoyl chloride (3.8 g, 0.01 mole) in acetone (10 ml) was successively added diethyl DL malate (1.9 g, 0.01 mole) in acetone (10 ml) and triethylamine (1.01 g, 0.01 mole) in acetone (5 ml). A white precipitate quickly formed. The reaction was heated to reflux for 24 hours. Upon cooling, the reaction was poured in water (75 ml) and extracted twice with methylene chloride (25 ml @). The combined organic extracts were successively washed with 5% sodium hydroxide and brine solutions. The dried solution was stripped of solvent to give 3.56 g of an amber oil.

1. customA white precipitate quickly formed
2. temperatureThe reaction was heated
3. temperatureto reflux for 24 hours
4. temperatureUpon cooling
5. extractionextracted twice with methylene chloride (25 ml @)
6. washThe combined organic extracts were successively washed with 5% sodium hydroxide and brine solutions