Potassium Carbonate → HCID 13689404, compound

HRID 979342Notes

Reaction equation

HRID 979342 reaction equation
[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.[Cl:21][C:22]1[CH:23]=[C:24]([CH:28]=[CH:29][CH:30]=1)[CH2:25][CH2:26]Cl.C([O-])([O-])=O.[K+].[K+]>C(OCCCC)(=O)C>[Cl:21][C:22]1[CH:23]=[C:24]([CH2:25][CH2:26][N:1]2[CH2:2][CH2:3][CH:4]([CH:7]3[C:13]4=[CH:14][CH:15]=[CH:16][N:12]4[CH2:11][C:10]4[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=4[O:8]3)[CH2:5][CH2:6]2)[CH:28]=[CH:29][CH:30]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepineHCID 143612151-Chloro-3-(2-chloroethyl)benzene

Product 1

HCID 13689404HCID 13689404, compound

Reagents, catalysts & solvents 1

HCID 31272Butyl AcetateSolvent

Procedure

A mixture of 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (6.05 g, 0.023 mole), 3-chlorophenethyl chloride (4.74 g, 0.027 mole), K2CO3 (10.9 g) and KI (0.1 g) in 130 ml n-butyl acetate was refluxed for 50 hours. The reaction mixture was cooled, filtered and concentrated to an oil.

Workup

  1. temperaturewas refluxed for 50 hours
  2. temperatureThe reaction mixture was cooled
  3. filtrationfiltered
  4. concentrationconcentrated to an oil

Sources & evidence

ORD record
ord-fcec3b01f05a496883d79b558ce44c36
Source dataset
uspto-grants-1987_05
Patent number
US04667039

Reaction notes

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