Sodium hydride → HCID 13851473, compound

HRID 979345Notes

Reaction equation

[Cl:1][C:2]1[CH:22]=[CH:21][C:5]([CH2:6][N:7]2[CH:11]=[CH:10][CH:9]=[C:8]2[CH:12]([CH:14]2[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]2)[OH:13])=[C:4](F)[CH:3]=1.[H-].[Na+]>>[Cl:1][C:2]1[CH:22]=[CH:21][C:5]2[CH2:6][N:7]3[CH:11]=[CH:10][CH:9]=[C:8]3[CH:12]([CH:14]3[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]3)[O:13][C:4]=2[CH:3]=1

Participants

Reactant 2

HCID 24758Sodium hydride

HCID 70431838HCID 70431838, compound

Product 1

HCID 13851473HCID 13851473, compound

Conditions

Temperature: 80 °C

Procedure

A mixture of [1-(4-chloro-2-fluorobenzyl)-2-pyrryl][(1-methyl)piperidin-4-yl]methanol (0.65 g, 0.002 mole) and sodium hydride (50% in oil, 0.12 g, 0.0023 mole, washed once with hexane) in 25 ml 20% DMF/benzene was heated at 80° C. for seven hours.

Workup

washwashed once with hexane) in 25 ml 20% DMF/benzene

Sources & evidence

ORD record: ord-ec04831e74fb4accbe7a55a6d9ad2c75
Source dataset: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04667039

Reaction notes

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