HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 979359Generated: October 30, 2026
Dichloromethane → 1-(Carboethoxy)methyliminomethyl-3,4-dimethoxybenzene
https://huagongshe.com/reaction/979359
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Veratraldehyde | HCID 8419 | — |
| Reactant | Sulfuric acid magnesium salt (1:1) | HCID 24083 | — |
| Reactant | Glycine ethyl ester, hydrochloride | HCID 2723640 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | 1-(Carboethoxy)methyliminomethyl-3,4-dimethoxybenzene | HCID 11299712 | — |
Reaction Steps
Alternatively, one may prepare compounds of the invention via the procedures of Scheme IV. In the first step, a benzaldehyde derivative is treated with ethyl glycinate hydrochloride in CH2Cl2, Et3N, and MgSO4 at room temperature to produce an imine ester of formula 24 (step 1). For example, 3,4-dimethoxybenzaldehyde is suspended in a CH2Cl2 solution of H2NCH2COOEt.HCl, Et3N and MgSO4 and stirred at 20° C. to produce 1-(carboethoxy)methyliminomethyl-3,4-dimethoxybenzene (24).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04667038 |
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| Source dataset | uspto-grants-1987_05 |
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| ORD ID | ord-24bbd5f003954f81a8e8b0004ffb74ae |
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| Source note | uspto-grants-1987_05 |
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