HRID979368

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

结构：CCOC(=O)C1(CCCC(C#N)(c2ccc(OC)c(OC)c2)C(C)C)Cc2cc(OC)c(OC)cc2CN1C

HCID20202228

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(C(C#N)(CCCC2(C(=O)O)Cc3cc(OC)c(OC)cc3C[NH+]2C)C(C)C)cc1OC.[Cl-]

HCID17996310

未命名化合物

PROCEDURE

实验过程

The resulting alkylated ester of formula 32 is then hydrolyzed by warming it in 6N HCl to produce a carboxylic acid/ammonium salt of formula 33 (step 4). For example, 3-carboethoxy-3-[4-(3,4-dimethoxyphenyl)-4-isopropyl-4-cyanobutyl]-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinoline (32) is heated at 35° C. in 6N HCl to produce 3-carboxy-3-[4-(3,4-dimethoxyphenyl)-4-isopropyl-4-cyanobutyl]-6,7-dimethoxy-N-methyl-1,2,3,4-tetrahydroisoquinolinium chloride (33).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-96dc3701217d454eb9357ebb9da8a3c0
来源数据集: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04667038
来源说明: uspto-grants-1987_05

反应 SMILES

[C:1]([C:6]1([CH2:21][CH2:22][CH2:23][C:24]([C:30]2[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([O:38][CH3:39])[CH:31]=2)([CH:27]([CH3:29])[CH3:28])[C:25]#[N:26])[CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:18][CH3:19])=[C:12]([O:16][CH3:17])[CH:13]=2)[CH2:8][N:7]1[CH3:20])([O:3]CC)=[O:2].[ClH:40]>>[Cl-:40].[C:1]([C:6]1([CH2:21][CH2:22][CH2:23][C:24]([C:30]2[CH:35]=[CH:34][C:33]([O:36][CH3:37])=[C:32]([O:38][CH3:39])[CH:31]=2)([CH:27]([CH3:29])[CH3:28])[C:25]#[N:26])[CH2:15][C:14]2[C:9](=[CH:10][C:11]([O:18][CH3:19])=[C:12]([O:16][CH3:17])[CH:13]=2)[CH2:8][NH+:7]1[CH3:20])([OH:3])=[O:2]