1-Bromo-2-Chloroethane → HCID 16109514, compound

HRID 979393Notes

Reaction equation

HRID 979393 reaction equation
[CH3:1][C:2]1([CH3:12])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([OH:11])[C:4]=2[O:3]1.Br[CH2:14][CH2:15][Cl:16].[OH-].[Na+]>CCCCCCCC[N+](CCCCCCCC)(CCCCCCCC)C.[Cl-].C(Cl)Cl>[CH3:1][C:2]1([CH3:12])[CH2:6][C:5]2[CH:7]=[CH:8][CH:9]=[C:10]([O:11][CH2:14][CH2:15][Cl:16])[C:4]=2[O:3]1

Participants

6

Reactant 3

HCID 78491-Bromo-2-ChloroethaneHCID 14798Sodium HydroxideHCID 152782,3-Dihydro-2,2-dimethyl-7-benzofuranol

Product 1

HCID 16109514HCID 16109514, compound

Reagents, catalysts & solvents 2

HCID 21218Trioctylmethylammonium chlorideCatalystHCID 6344DichloromethaneSolvent

Procedure

To 200 ml. methylene-chloride 32.84 g. (0.2 mole) 2,3-dihydro-2,2-dimethyl-7-hydroxy-benzofuran, 57.37 g. (0.4 mole) 1-bromo-2-chloro-ethane 200 ml. 2N sodium hydroxide solution and 8 g. Adogen 464 phase transfer catalyst (tri-C8-10 -alkyl-methyl-ammonium-chloride) are added. The reaction mixture is heated under vigorous stirring for 7 hours and the reaction is monitored by gas chromatographic analysis.

Workup

  1. temperatureThe reaction mixture is heated

Sources & evidence

ORD record
ord-53dbd3f7219e4ebe9551f473c41a6134
Source dataset
uspto-grants-1987_05
Patent number
US04668274

Reaction notes

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