Water → HCID 44267586, compound

HRID 979434Notes

Reaction equation

HRID 979434 reaction equation
Br[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]/[CH:7]=[C:8](\[NH:12][C:13]([CH:15]1[CH2:17][C:16]1([CH3:19])[CH3:18])=[O:14])/[C:9]([OH:11])=[O:10].[CH3:20][NH:21][CH2:22][C:23]([OH:25])=[O:24].C([O-])([O-])=O.[Na+].[Na+].O>N#N>[C:23]([CH2:22][N:21]([CH3:20])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]/[CH:7]=[C:8](\[NH:12][C:13]([CH:15]1[CH2:17][C:16]1([CH3:19])[CH3:18])=[O:14])/[C:9]([OH:11])=[O:10])([OH:25])=[O:24]

Participants

6

Reactant 4

HCID 962WaterHCID 1088SarcosineHCID 10340Sodium CarbonateHCID 13505574HCID 13505574, compound

Product 1

HCID 44267586HCID 44267586, compound

Reagents, catalysts & solvents 1

HCID 947NitrogenSolvent

Procedure

3.32 g of Z-8-bromo-2-(2,2-dimethylcyclopropanecarboxamido)-2-octenoic acid, 1.0 g of CH3NHCH2CO2H, 3.5 g of Na2CO3 and 30 ml of water were heated at 80° C. in N2 for 1.5 hours. After purification, 1.01 g of product was prepared, calc for C17H28N2O5.2H2O: C, 54.24; H, 8.57; N, 7.44; found: C, 54.40; H, 8.34; N, 7.16.

Workup

  1. customAfter purification, 1.01 g of product
  2. customwas prepared

Sources & evidence

ORD record
ord-ef16d1c4d0544daaa4e03cb3fa7db7e5
Source dataset
uspto-grants-1987_05
Patent number
US04668504

Reaction notes

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