Methyl iodide → HCID 15692309, compound

HRID 979484Notes

Reaction equation

HRID 979484 reaction equation
[OH:1][CH2:2][CH:3]([CH2:18][OH:19])[C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][CH2:6][N:5]=1.[CH3:20][I:21]>C(O)C>[I-:21].[OH:1][CH2:2][CH:3]([CH2:18][OH:19])[C:4]1[C:13]2[C:8](=[CH:9][C:10]([O:16][CH3:17])=[C:11]([O:14][CH3:15])[CH:12]=2)[CH2:7][CH2:6][N+:5]=1[CH3:20]

Participants

4

Reactant 2

HCID 6328Methyl iodideHCID 136966801-[Bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline

Product 1

HCID 15692309HCID 15692309, compoundYield 71%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

0.03 mole (7.96 g) of 1-[bis(hydroxymethyl)-methyl]-6,7-dimethoxy-3,4-dihydroisoquinoline is dissolved in 40 ml of absolute ethanol. 0.045 mole (6.39 g) of methyl iodide is added to the solution and the reaction mixture is kept at 30° to 40° C. for 6 hours. The precipitated crystals are filtered off and recrystallized from ethanol. The aimed compound is obtained with a melting point of 189° to 193° C.

Workup

  1. filtrationThe precipitated crystals are filtered off
  2. customrecrystallized from ethanol

Sources & evidence

ORD record
ord-ab34157409794e6996a4e6b9bc123207
Source dataset
uspto-grants-1987_05
Patent number
US04668688

Reaction notes

Loading…