Hydrochloric Acid → HCID 20200517, compound

Participants

Reaction Steps

If desired, acid addition salts of the Formula I products can be prepared by acidifying the residual material in an appropriate solvent. For instance, treating 8-methyl-1,3,9,9a-tetrahydro-2H-imidazo[4,5-b]quinolin-2-one with iodine as above and dissolving the insoluble product in a 10% methanolic hydrogen chloride solution followed by addition of diethyl ether provided a 72% yield of 8-methyl-1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one hydrochloride, m.p. 360°-363° C.

Provenance & Evidence