Hydrochloric Acid → HCID 20200517, compound

HRID 979516Notes

Reaction equation

HRID 979516 reaction equation
[CH3:1][C:2]1[C:3]2[CH2:4][CH:5]3[NH:14][C:13](=[O:15])[NH:12][C:6]3=[N:7][C:8]=2[CH:9]=[CH:10][CH:11]=1.II.C(OCC)C.[ClH:23]>>[ClH:23].[CH3:1][C:2]1[C:3]2[CH:4]=[C:5]3[NH:14][C:13](=[O:15])[NH:12][C:6]3=[N:7][C:8]=2[CH:9]=[CH:10][CH:11]=1

Participants

5

Reactant 4

HCID 313Hydrochloric AcidHCID 807IodineHCID 3283Diethyl EtherHCID 135626414HCID 135626414, compound

Product 1

HCID 20200517HCID 20200517, compoundYield 72%

Procedure

If desired, acid addition salts of the Formula I products can be prepared by acidifying the residual material in an appropriate solvent. For instance, treating 8-methyl-1,3,9,9a-tetrahydro-2H-imidazo[4,5-b]quinolin-2-one with iodine as above and dissolving the insoluble product in a 10% methanolic hydrogen chloride solution followed by addition of diethyl ether provided a 72% yield of 8-methyl-1,3-dihydro-2H-imidazo[4,5-b]quinolin-2-one hydrochloride, m.p. 360°-363° C.

Workup

  1. additionacid addition salts of the Formula I products
  2. customcan be prepared

Sources & evidence

ORD record
ord-58636cc1801b409192811062fc562683
Source dataset
uspto-grants-1987_05
Patent number
US04668686

Reaction notes

Loading…