HCID 13922926, compound → HCID 178448724, compound

HRID 979646Notes

Reaction equation

HRID 979646 reaction equation
[C:1]([C:3]1[C:8]([O:9][CH3:10])=[C:7]([O:11][CH3:12])[CH:6]=[CH:5][C:4]=1[NH:13][C:14]([NH:16][CH2:17][CH2:18][CH2:19][CH3:20])=[O:15])#[N:2]>C[O-].[Na+]>[CH2:17]([N:16]1[C:1](=[NH:2])[C:3]2[C:4](=[CH:5][CH:6]=[C:7]([O:11][CH3:12])[C:8]=2[O:9][CH3:10])[NH:13][C:14]1=[O:15])[CH2:18][CH2:19][CH3:20]

Participants

3

Reactant 1

HCID 13922926HCID 13922926, compound

Product 1

HCID 178448724HCID 178448724, compoundYield 69.2%

Reagents, catalysts & solvents 1

HCID 10942334Sodium MethoxideSolvent

Procedure

A mixture of 1-(2-cyano-3,4-dimethoxyphenyl)-3-butyl urea (5.2 g, 18.8 mmol) in 50 ml of 0.5N methanolic sodium methoxide was heated at reflux under nitrogen for 18 hours. The reaction solution was cooled and a precipitate which formed was collected, washed with cold methanol and dried giving 3.61 g (68.4%) of analytical product, mp 165°-168°.

Workup

  1. temperaturewas heated
  2. temperatureat reflux under nitrogen for 18 hours
  3. temperatureThe reaction solution was cooled
  4. customa precipitate which formed
  5. customwas collected
  6. washwashed with cold methanol
  7. customdried

Sources & evidence

ORD record
ord-b78292f112d7482e988d3cfb3f8b2c6f
Source dataset
uspto-grants-1987_05
Patent number
US04668787

Reaction notes

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