Allylamine → HCID 13370641, compound

HRID 979670Notes

Reaction equation

[O:1]1[CH2:28][CH:2]1[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:27])[C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:12]2)=[CH:7][CH:6]=1.[CH2:29]([NH2:32])[CH:30]=[CH2:31]>>[CH2:29]([NH:32][CH2:28][CH:2]([OH:1])[CH2:3][O:4][C:5]1[CH:14]=[C:13]2[C:8]([C:9](=[O:27])[C:10]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=3)=[C:11]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[O:12]2)=[CH:7][CH:6]=1)[CH:30]=[CH2:31]

Participants

Reactant 2

HCID 7853Allylamine

HCID 13370622HCID 13370622, compound

Product 1

HCID 13370641HCID 13370641, compound

Procedure

Using Method B, the reaction of 7-(2,3-epoxypropoxy)-2,3-diphenychromone and allylamine afforded the desired amine as white needles, m.p. 119- (iPrOH); yield, 82%. Its hydrochloride salt had m.p. 140°-142° (iPrOH/PhCH3); containing water).

Sources & evidence

ORD record: ord-5548dd986971483186ec24995ad13de2
Source dataset: uspto-grants-1987_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04668805

Reaction notes

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