Dimethylformamide → HCID 20200957, compound
Reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:11]([CH:15]([CH3:17])[CH3:16])[C:12](O)=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH3:10].CN(C)C=O.S(Cl)([Cl:25])=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([CH:11]([CH:15]([CH3:17])[CH3:16])[C:12]([Cl:25])=[O:13])[CH:5]=[CH:6][C:7]=1[O:8][CH2:9][CH3:10]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 40 °C
Procedure
Into a solution of 0.15 g (0.62 mM) of 2-(3-fluoro-4-ethoxyphenyl)isovaleric acid in 3.0 ml of anhydrous methylene chloride, a catalytic amount of dimethylformamide and 0.16 g (1.37 mM) of thionyl chloride were added, and the mixture was stirred for 2 hours in an oil bath at 40° C. Thereafter, an excess of thionyl chloride and methylene chloride were distilled off from the reaction mixture under a reduced pressure to obtain 2-(3-fluoro-4-ethoxyphenyl)isovaleric chloride as an oily substance.
Workup
- distillationThereafter, an excess of thionyl chloride and methylene chloride were distilled off from the reaction mixture under a reduced pressure
Sources & evidence
- ORD record
- ord-36cb5ad2ff4e4521a44df6353bdc8def
- Source dataset
- uspto-grants-1987_05
- Patent number
- US04668815
Reaction notes
Loading…