HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 7-(Chloromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Ethyl 4-chloroacetoacetate | HCID 69484 | — |
| Product | 7-(Chloromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one | HCID 2063597 | — |
Reaction Steps
The intermediate 7-(chloromethyl)-5H-thiazolo[3,2-a]pyrimidin-5-one was prepared from 2-thiazolamine and ethyl 4-chloroacetoacetate by the procedure described in EXAMPLE 1. The m.p. was 132°-136° C., and the structure was confirmed by NMR and IR.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04634690 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-0aca1be291e04553b65509409a914278 |
| Source note | uspto-grants-1987_01 |