2-Aminothiazole → 7-(Chloromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

HRID 979770Notes

Reaction equation

HRID 979770 reaction equation
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[NH2:6].[Cl:7][CH2:8][C:9](=O)[CH2:10][C:11](OCC)=[O:12]>>[Cl:7][CH2:8][C:9]1[N:6]=[C:2]2[S:1][CH:5]=[CH:4][N:3]2[C:11](=[O:12])[CH:10]=1

Participants

3

Reactant 2

HCID 21552-AminothiazoleHCID 69484Ethyl 4-chloroacetoacetate

Product 1

HCID 20635977-(Chloromethyl)-5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one

Procedure

The intermediate 7-(chloromethyl)-5H-thiazolo[3,2-a]pyrimidin-5-one was prepared from 2-thiazolamine and ethyl 4-chloroacetoacetate by the procedure described in EXAMPLE 1. The m.p. was 132°-136° C., and the structure was confirmed by NMR and IR.

Sources & evidence

ORD record
ord-0aca1be291e04553b65509409a914278
Source dataset
uspto-grants-1987_01
Patent number
US04634690

Reaction notes

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