Allyl bromide → HCID 20223008, compound

HRID 979804Notes

Reaction equation

HRID 979804 reaction equation
[F:1][C:2]1[C:3]([O:9][CH3:10])=[C:4]([OH:8])[CH:5]=[CH:6][CH:7]=1.C(=O)([O-])[O-].[K+].[K+].[CH2:17](Br)[CH:18]=[CH2:19]>CC(C)=O>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([O:8][CH2:19][CH:18]=[CH2:17])[C:3]=1[O:9][CH3:10]

Participants

5

Reactant 3

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 134373473-Fluoro-2-methoxyphenol

Product 1

HCID 20223008HCID 20223008, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

A mixture of 3-fluoro-2-methoxyphenol (19.5 g; 0.137 m) potassium carbonate (85 g), allyl bromide (15 ml) and acetone (100 ml) was refluxed for 4 hours. The reaction was cooled to room temperature and evaporated to dryness. The residue was partitioned between water and dichloromethane. The organic layer was separated, dried and evaporated affording 19.0 g of the desired product as an oil.

Workup

  1. temperaturewas refluxed for 4 hours
  2. customevaporated to dryness
  3. customThe residue was partitioned between water and dichloromethane
  4. customThe organic layer was separated
  5. customdried
  6. customevaporated

Sources & evidence

ORD record
ord-80395b594811469eac11e42b8be3971a
Source dataset
uspto-grants-1987_01
Patent number
US04634705

Reaction notes

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