Pyridine → HCID 70434270, compound

HRID 979810Notes

Reaction equation

HRID 979810 reaction equation
[NH2:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][CH:7]2C#N.[CH3:16][S:17](Cl)(=[O:19])=[O:18].[N:21]1C=CC=C[CH:22]=1>O>[C:22]([CH2:16][S:17]([NH:1][C:2]1[C:11]([O:12][CH3:13])=[CH:10][CH:9]=[C:8]2[C:3]=1[CH2:4][CH2:5][CH2:6][CH2:7]2)(=[O:19])=[O:18])#[N:21]

Participants

5

Reactant 3

HCID 1049PyridineHCID 31297Methanesulfonyl chlorideHCID 20222960HCID 20222960, compound

Product 1

HCID 70434270HCID 70434270, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A solution of the product from Example 77 (2.5 g) in pyridine (10 ml) was treated with methanesulfonyl chloride (2 ml). After 4 hours stirring at room temperature the reaction was diluted with water and the mixture was filtered and dried affording 2.76 of product (80% yield).

Workup

  1. filtrationthe mixture was filtered
  2. customdried

Sources & evidence

ORD record
ord-1aa087899d6c49db8dbfa649a279af1a
Source dataset
uspto-grants-1987_01
Patent number
US04634705

Reaction notes

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