Lithium cyanide → HCID 70433632, compound

Participants

Reaction Conditions

Reaction Steps

The product from Example 96 (0.2 g) was dissolved in tetrahydrofuran (15 ml), cooled to -15° C. and treated with lithium cyanide (20 mg) and diethyl cyanophosphonate (0.2 ml). After 30 minutes, the reaction was quenched with water and extracted with ethyl acetate. The organic layer was separated, dried and the solvent evaporated. The residue was dissolved in benzene (30 ml) and a catalytic amount of p-toluenesulfonic acid was added. The reaction was refluxed for 30 minutes, quenched with 5% sodium bicarbonate, and extracted with ether. The organic layer was separated, dried and the solvent evaporated in vacuo affording the desired product in 95% yield.

Provenance & Evidence