Hydrochloric Acid → 5,7-dihydro-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one dihydrochloride

HRID 979858Notes

Reaction equation

HRID 979858 reaction equation
[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][N:6]=[C:5]([CH2:10][S:11][C:12]2[NH:16][C:15]3[CH:17]=[C:18]4[C:22](=[CH:23][C:14]=3[N:13]=2)[C:21]([CH3:25])([CH3:24])[C:20](=[O:26])[C:19]4([CH3:28])[CH3:27])[C:4]=1[CH3:29].[ClH:30]>CO>[ClH:30].[ClH:30].[CH3:1][O:2][C:3]1[C:8]([CH3:9])=[CH:7][N:6]=[C:5]([CH2:10][S:11][C:12]2[NH:13][C:14]3[CH:23]=[C:22]4[C:18](=[CH:17][C:15]=3[N:16]=2)[C:19]([CH3:27])([CH3:28])[C:20](=[O:26])[C:21]4([CH3:25])[CH3:24])[C:4]=1[CH3:29]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 221514375,7-dihydro-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)-methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one

Product 1

HCID 221514505,7-dihydro-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one dihydrochloride

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

2.6 g of 5,7-dihydro-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one were dissolved in 50 ml of hot methanol and the solution was boiling under reflux for 10 minutes with 50 ml of a 4N solution of hydrogen chloride in methanol. After concentration in vacuo the residue was crystallized from ether and there was obtained 5,7-dihydro-2-[[(4-methoxy-3,5-dimethyl-2-pyridyl)methyl]thio]-5,5,7,7-tetramethylindeno[5,6-d]imidazol-6(1H)-one dihydrochloride of melting point 165°-170°.

Workup

  1. concentrationAfter concentration in vacuo the residue
  2. customwas crystallized from ether

Sources & evidence

ORD record
ord-c97212f565c647fea59b7b65c71811b9
Source dataset
uspto-grants-1987_01
Patent number
US04634710

Reaction notes

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