反应详情

A mixture of 4213 g of 1-(p-acetamidophenyl)-2-imidazolidinone in 39,000 ml of water and 2930 g of 5% rhodium on carbon 50% wet with water is hydrogenated at 40°. The hydrogenation mixture is filtered, and the filtrate is concentrated in vacuo to dryness. The resulting solid is air-dried and then powdered. The crude product is recrystallized from 12,000 ml of acetone to give 1-(4-acetamidocyclohexyl)-2-imidazolidinone, m.p. 211°-230° as a mixture of cis and trans isomers.

1. customis hydrogenated at 40°
2. filtrationThe hydrogenation mixture is filtered
3. concentrationthe filtrate is concentrated in vacuo to dryness
4. customThe resulting solid is air-dried
5. customThe crude product is recrystallized from 12,000 ml of acetone