Sodium Methoxide → N-(4-Aminocyclohexyl)-N'-ethylurea

HRID 979897Notes

Reaction equation

HRID 979897 reaction equation
Cl.[NH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH2:5][CH2:4]1.C[O-].[Na+]>CO>[NH2:2][CH:3]1[CH2:8][CH2:7][CH:6]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[CH2:5][CH2:4]1

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 13755493N-(4-Aminocyclohexyl)-N'-ethylurea--hydrogen chloride (1/1)

Product 1

HCID 13755492N-(4-Aminocyclohexyl)-N'-ethylurea

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 1.5 g of 1-(4-aminocyclohexyl)-3-ethylurea hydrochloride in 20 ml of methyl alcohol is treated with 0.36 g of sodium methoxide, to yield after usual workup 1-(4-aminocyclohexyl)-3-ethylurea as an oil which is used directly in the above condensation.

Sources & evidence

ORD record
ord-7d56d3b0490c46be9553e42cbfec1836
Source dataset
uspto-grants-1987_01
Patent number
US04634713

Reaction notes

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