反应详情

A solution of 3.7 g of cis 1-(4-aminocyclohexyl)-2-imidazolidinone and 4.7 g of p-(cyclopropylmethoxy)-phenoxymethyloxirane in 50 ml of isopropanol is stirred at reflux for 6 hours. After standing at room temperature 16 hours, the solution is treated with 1.17 g of fumaric acid and heated at reflux for 30 minutes. A solid precipitates, the reaction mixture is cooled to room temperature, the product is filtered off, washed with isopropanol, and dried in vacuo at 65° to yield cis-1-{4-[3-(p-cyclopropylmethoxyphenoxy)-2-hydroxypropylamino]-cyclohexyl}-2-imidazolidone hemifumarate, m.p. 163°-165°.

1. temperatureat reflux for 6 hours
2. temperatureheated
3. temperatureat reflux for 30 minutes
4. customA solid precipitates
5. filtrationthe product is filtered off
6. washwashed with isopropanol
7. customdried in vacuo at 65°