HRID979959

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：CN(NC(CCCCN1C(=O)c2ccccc2C1=O)C(=O)OCc1ccccc1)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C

HCID18606049

未命名化合物

PRODUCTS

产物

反应SMILES：CN(NC(CCCCN1C(=O)c2ccccc2C1=O)C(=O)O)C(=O)N1CCC[C@H]1C(=O)OC(C)(C)C

HCID18606065

未命名化合物

收率 96.7%

AUXILIARIES

试剂、催化剂与溶剂

催化剂HCID23938

Palladium

溶剂HCID176

Acetic Acid

C2H4O2

溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A solution of azapeptide ester 24 (0.402 g; 0.679 mmol) in ethyl acetate (5 ml) and acetic acid (0.2 ml) was hydrogenated with 110 mg of 10% Pd C for 18 hours. Filtration of catalyst and removal of solvent gave azapeptide 25 as a white foam (0.330 g). TLC (silica gel; EPAW 20:5:1:1) Rf=0.7. MS m/e 574 (M+, monotrimethylsilyl). NMR (CDCl3): δ1.42 (9H.s); 1.5-2.1 (10H,m); 3.00 (3H,s); 3.4-3.8 (5H,m); 4.3-4.6 (1H,m); 7.6-7.8 (4H,m); 7.8-8.0 (1H, broad).

WORKUP

后处理

filtrationFiltration of catalyst and removal of solvent

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-bbccc7cf8b4946ab938246fc04b88db1
来源数据集: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US04634715
来源说明: uspto-grants-1987_01

反应SMILES

[C:1]([O:5][C:6](=[O:43])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:42])[N:13]([CH3:41])[NH:14][CH:15]([C:31]([O:33]CC1C=CC=CC=1)=[O:32])[CH2:16][CH2:17][CH2:18][CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])([CH3:4])([CH3:3])[CH3:2]>C(OCC)(=O)C.C(O)(=O)C.[Pd]>[C:1]([O:5][C:6](=[O:43])[C@@H:7]1[CH2:11][CH2:10][CH2:9][N:8]1[C:12](=[O:42])[N:13]([CH3:41])[NH:14][CH:15]([C:31]([OH:33])=[O:32])[CH2:16][CH2:17][CH2:18][CH2:19][N:20]1[C:24](=[O:25])[C:23]2=[CH:26][CH:27]=[CH:28][CH:29]=[C:22]2[C:21]1=[O:30])([CH3:4])([CH3:2])[CH3:3]