反应详情

A 24.3 g (0.10 mole) quantity of methyl 5-chloro-3-propionylsalicylate was added to a solution of 0.5 g (0.022 mole) of sodium in 300 ml of morpholinoethanol. The mixture was maintained at room temperature for 24 hours and was heated at 2 hours at 90° C. The reaction mixture was subjected to distillation at reduced pressure to remove the excess unreacted morpholinoethanol and the methanol produced, and the residue was recrystallized from cyclohexane to obtain 38.0 g (88.8%) of crystals which melt at 144.0° to 146.3° C.

1. temperaturewas heated at 2 hours at 90° C
2. distillationThe reaction mixture was subjected to distillation at reduced pressure
3. customto remove the excess unreacted morpholinoethanol
4. customthe methanol produced
5. customthe residue was recrystallized from cyclohexane