Hydrochloric Acid → HCID 13335989, compound

HRID 979989Notes

Reaction equation

[ClH:1].Br[C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([C:13]([O:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[O:14])[CH:12]=1)[O:9][C:8]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[C:7]([CH3:30])[C:6]2=[O:31]>>[Cl:1][C:3]1[CH:4]=[C:5]2[C:10](=[C:11]([C:13]([O:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][O:21][CH2:20][CH2:19]3)=[O:14])[CH:12]=1)[O:9][C:8]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)=[C:7]([CH3:30])[C:6]2=[O:31]

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 13335998HCID 13335998, compound

Product 1

HCID 13335989HCID 13335989, compound

Procedure

The procedure of Example 13 was repeated with the exception of using 37.3 g (0.10 mole) of methyl 6-bromo-3-methylflavone-8-carboxylate in place of methyl 6-chloro-3-methylflavone-8-carboxylate, giving 44 g (93.2%) of crystals. The hydrochloride of the product melts at 205.0° to 208.0° C. The crystals were found to be identical with the product obtained in Example 9.

Sources & evidence

ORD record: ord-52ac5717b32c47db863f1000bd8b7813
Source dataset: uspto-grants-1987_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04634768

Reaction notes

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