Diethyl Ether → HCID 20159920, compound

HRID 980009Notes

Reaction equation

HRID 980009 reaction equation
C(OC([NH:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15])=O)(C)(C)C.C(OCC)C>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH:10]([C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1)[CH2:11][CH2:12][NH:13][S:14]([C:17]1[C:18]2[CH:19]=[CH:20][N:21]=[CH:22][C:23]=2[CH:24]=[CH:25][CH:26]=1)(=[O:16])=[O:15]

Participants

4

Reactant 2

HCID 3283Diethyl EtherHCID 20159947HCID 20159947, compound

Product 1

HCID 20159920HCID 20159920, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

In 30 ml of trifluoroacetic acid was dissolved 6.0 g of N-(4-t-butoxycarbonylamino-3-phenylbutyl)-5-isoquinolinesulfonamide, and left at a temperature of 20° C.~25° C. for 30 minutes. The mixrure was condensed under reduced pressure. To the reaction solution was added ethyl ether, and the crystals precipitated were separated by filtration. The crystals thus obtained were washed with ethylether to give 4.54 g of N-(4-amino-3-phenylbutyl)-5-isoquinolinesulfonamide in a yield of 97%.

Workup

  1. customcondensed under reduced pressure
  2. customthe crystals precipitated
  3. customwere separated by filtration
  4. customThe crystals thus obtained
  5. washwere washed with ethylether

Sources & evidence

ORD record
ord-a15db979ebc54b889a356f3f03824796
Source dataset
uspto-grants-1987_01
Patent number
US04634770

Reaction notes

Loading…