Pyrazine → 1-(2-Pyrazinyl)-2,2-dimethylpropanone

HRID 980073Notes

Reaction equation

HRID 980073 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][CH:2]=1.[CH3:7][C:8]([CH3:12])([CH3:11])[CH:9]=[O:10]>C(Cl)Cl>[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[C:9](=[O:10])[C:8]([CH3:12])([CH3:11])[CH3:7]

Participants

4

Reactant 2

HCID 9261PyrazineHCID 12417Pivalaldehyde

Product 1

HCID 5460311-(2-Pyrazinyl)-2,2-dimethylpropanoneYield 11%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The reaction of pyrazine and trimethylacetaldehyde is conducted in the manner described in Example I on the same molar scale. Preparative thick layer chromatography (2000μ silica gel GF, developed with methylene chloride) of the crude reaction product provides an 11% yield of 1-pyrazinyl-2,2-dimethyl-1-propanone.

Sources & evidence

ORD record
ord-aed44738abcf4a63a26908cf73982928
Source dataset
uspto-grants-1987_01
Patent number
US04635652

Reaction notes

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