HuagongsheHuagongshe Chemistry Print Report · For research reference only
Pyrazine → 1-(2-Pyrazinyl)-2,2-dimethylpropanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Pyrazine | HCID 9261 | — |
| Reactant | Pivalaldehyde | HCID 12417 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Pyrazinyl)-2,2-dimethylpropanone | HCID 546031 | 11% |
Reaction Steps
The reaction of pyrazine and trimethylacetaldehyde is conducted in the manner described in Example I on the same molar scale. Preparative thick layer chromatography (2000μ silica gel GF, developed with methylene chloride) of the crude reaction product provides an 11% yield of 1-pyrazinyl-2,2-dimethyl-1-propanone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04635652 |
| Source dataset | uspto-grants-1987_01 |
| ORD ID | ord-aed44738abcf4a63a26908cf73982928 |
| Source note | uspto-grants-1987_01 |