Dichloroacetyl chloride → HCID 13125046, compound

HRID 980077Notes

Reaction equation

HRID 980077 reaction equation
[CH:1]([CH:4]1[NH:8][C:7](=[O:9])[CH2:6][NH:5]1)([CH3:3])[CH3:2].[OH-].[Na+].[Cl:12][CH:13]([Cl:17])[C:14](Cl)=[O:15]>C(OC)(C)(C)C.O>[Cl:12][CH:13]([Cl:17])[C:14]([N:5]1[CH2:6][C:7](=[O:9])[NH:8][CH:4]1[CH:1]([CH3:3])[CH3:2])=[O:15]

Participants

6

Reactant 3

HCID 6593Dichloroacetyl chlorideHCID 14798Sodium HydroxideHCID 13125043HCID 13125043, compound

Product 1

HCID 13125046HCID 13125046, compoundYield 49%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 15413tert-Butyl methyl etherSolvent

Procedure

45 g (0.35 mole) of 2-isopropyl-4-oxo-imidazolidine (Example 3) were dissolved in 250 ml of methyl tert.-butyl ether, 17.2 g (0.43 mole) of sodium hydroxide in 20 ml of water were added, and 57 g (0.39 mole) of dichloroacetyl chloride were then added dropwise at from 10° to 15° C. The mixture was stirred for 10 hours and the solid precipitate was filtered off with suction, washed with water and dried under reduced pressure to give 41 g (49% of theory) of 1-dichloroacetyl-2-isopropyl-4-oxo-imidazolidine of melting point 172°-173° C.

Workup

  1. filtrationthe solid precipitate was filtered off with suction
  2. washwashed with water
  3. customdried under reduced pressure

Sources & evidence

ORD record
ord-8d22e7055fe844189d50e7db6c2d3baf
Source dataset
uspto-grants-1987_01
Patent number
US04636246

Reaction notes

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