Benzene → HCID 12962300, compound

HRID 980083Notes

Reaction equation

HRID 980083 reaction equation
[CH2:1]([CH:3]1[NH:7][CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4]1)[CH3:2].C1C=CC=CC=1.[Cl:20][CH:21]([Cl:25])[C:22](Cl)=[O:23]>C(N(CC)CC)C>[CH2:1]([CH:3]1[N:7]([C:22](=[O:23])[CH:21]([Cl:25])[Cl:20])[CH2:6][CH:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)[O:4]1)[CH3:2]

Participants

5

Reactant 3

HCID 241BenzeneHCID 6593Dichloroacetyl chlorideHCID 20221973HCID 20221973, compound

Product 1

HCID 12962300HCID 12962300, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Twenty-one and three tenths (21.3) ml. of a solution containing 5.3 g. of 2-ethyl-5-phenyl oxazolidine was diluted with 25 ml. of benzene and 3.1 g. of triethylamine was added. The mixture was cooled in a room temperature water bath and 4.4 g. of dichloroacetyl chloride was added dropwise with stirring. The stirring was continued for about 30 minutes after addition was complete. The solution was washed with water, separated, dried over magnesium sulfate and removed under vacuum. There was obtained a yield of 8.7 g. of the title compound, an oil, ND30 =1.5600.

Workup

  1. additionof a solution containing 5.3 g
  2. additionafter addition
  3. washThe solution was washed with water
  4. customseparated
  5. dry with materialdried over magnesium sulfate
  6. customremoved under vacuum
  7. customThere was obtained a yield of 8.7 g

Sources & evidence

ORD record
ord-33478a2ae36e44f0887d2cb203df29cc
Source dataset
uspto-grants-1987_01
Patent number
US04636244

Reaction notes

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