Benzene → HCID 12962334, compound

HRID 980089Notes

Reaction equation

HRID 980089 reaction equation
[C:1]1([CH:7]2[O:11][CH2:10][NH:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.C1C=CC=CC=1.[Br:18][CH2:19][CH2:20][C:21](Cl)=[O:22]>C(N(CC)CC)C>[Br:18][CH2:19][CH2:20][C:21]([N:9]1[CH2:8][CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[O:11][CH2:10]1)=[O:22]

Participants

5

Reactant 3

HCID 241BenzeneHCID 84944Propanoyl chloride, 3-bromo-HCID 15261642HCID 15261642, compound

Product 1

HCID 12962334HCID 12962334, compound

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

Four and five tenths (4.5) grams of 5-phenyl oxazolidine contained in 44.7 g. of benzene solution was mixed with 3.1 g. of triethylamine and stirred in a room temperature water bath, while 5.2 g. of 3-bromopropionyl chloride was added dropwise. After standing for about 30 minutes, the solution was washed with water, separated, dried over magnesium sulfate and the solvent stripped under vacuum. There was obtained a yield of 6 g. of an oil, the title compound, ND30 =1.5591.

Workup

  1. washthe solution was washed with water
  2. customseparated
  3. dry with materialdried over magnesium sulfate
  4. customThere was obtained a yield of 6 g

Sources & evidence

ORD record
ord-17642810bc3a45e4b66113db5a779e17
Source dataset
uspto-grants-1987_01
Patent number
US04636244

Reaction notes

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