Triethylamine → HCID 19870276, compound

HRID 980118Notes

Reaction equation

HRID 980118 reaction equation
[CH2:1]([CH:9]1[O:14][CH2:13][CH2:12][NH:11][CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8].Cl[CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21].C(N(CC)CC)C>C1(C)C=CC=CC=1>[CH2:1]([CH:9]1[O:14][CH2:13][CH2:12][N:11]([CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][OH:21])[CH2:10]1)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6][CH2:7][CH3:8]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 789155-Chloro-1-pentanolHCID 19764216HCID 19764216, compound

Product 1

HCID 19870276HCID 19870276, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

20.0 grams (0.1 mole) 2-octylmorpholine, 13 grams (0.1 mole) of 5-chloropentanol and 12 grams of triethylamine in 150 ml. toluene were kept at 140°-150° C. for 12 hours in an autoclave. After cooling, the organic phase was washed twice with water, dried, and the solvent was evaporated and the base distilled at 128° C./0.01 mm Hg.; yield: 22.0 grams (77%).

Workup

  1. temperatureAfter cooling
  2. washthe organic phase was washed twice with water
  3. customdried
  4. customthe solvent was evaporated
  5. distillationthe base distilled at 128° C./0.01 mm Hg

Sources & evidence

ORD record
ord-d7acadc6b7c64015a2d9d15847d69338
Source dataset
uspto-grants-1987_01
Patent number
US04636382

Reaction notes

Loading…