反应详情

28 g of 2-phenoxycarbonyl-1,4-dihydroxynaphthalene was dissolved in ethanol under a nitrogen stream, and 20.4 g of sodium ethylate was added thereto, followed by refluxing for 5 hours under heating. After being cooled, the solution was made weakly acidic with acetic acid, then ethanol was distilled off. Ethyl acetate and water were added thereto to separate and extract the product. The product was purified through silica gel column chromatography with an element having the same composition as that used in the Synthesis Example 1 to obtain compound (6) as crytals. Yield: 13 g (56%).

1. additionwas added
2. temperatureby refluxing for 5 hours
3. temperatureunder heating
4. temperatureAfter being cooled
5. distillationethanol was distilled off
6. additionEthyl acetate and water were added
7. customto separate
8. extractionextract the product
9. customThe product was purified through silica gel column chromatography with an element
10. customthat used in the Synthesis Example 1