HCID 178418311, compound → HCID 178528013, compound

HRID 980124Notes

Reaction equation

HRID 980124 reaction equation
CS[C:3](=[S:10])[NH:4][C:5]1[N:9]=[CH:8][NH:7][N:6]=1.[NH2:11][C:12]1[N:16]=[CH:15][NH:14][N:13]=1>CN(C)C=O>[NH:14]1[CH:15]=[N:16][C:12]([NH:11][C:3]([NH:4][C:5]2[N:9]=[CH:8][NH:7][N:6]=2)=[S:10])=[N:13]1

Participants

4

Reactant 2

HCID 178418311HCID 178418311, compoundHCID 178504094HCID 178504094, compound

Product 1

HCID 178528013HCID 178528013, compoundYield 58%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

A 3,000 ml multinecked flask provided with a reflux condenser and placed on a water bath was filled with 156.2 g (0.8964 mole) of N-1,2,4-triazolyl-dithiocarbamic acid methyl ester, prepared as described in U.S. Pat. No. 3,686,201, 1,700 ml of dimethylformamide, 75.37 g (0.8964 mole) of 3-amino-1,2,4-triazole. The reaction mixture was heated for 24 hours thus obtaining first a solution and then the formation of a precipitate. The suspension was filtered, the product thus obtained washed with methanol and then dried thus obtaining 109.3 g of a white product (Yield 57%).

Workup

  1. customprovided with a reflux condenser
  2. customplaced on a water bath
  3. customprepared
  4. temperatureThe reaction mixture was heated for 24 hours
  5. customthus obtaining first a solution
  6. filtrationThe suspension was filtered
  7. customthe product thus obtained
  8. washwashed with methanol
  9. customdried thus

Sources & evidence

ORD record
ord-747c5ea60bb84c9f85b3534f6014dc5c
Source dataset
uspto-grants-1987_01
Patent number
US04636457

Reaction notes

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