HCID 13569176, compound → HCID 13569190, compound

HRID 980141Notes

Reaction equation

HRID 980141 reaction equation
[ClH:1].[N:2]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:16][C:17]([O:19]CC)=[O:18])[CH:6]=[CH:5][N:4]=[CH:3]1>Cl>[ClH:1].[N:2]1([CH2:7][CH2:8][O:9][C:10]2[CH:15]=[CH:14][CH:13]=[CH:12][C:11]=2[CH2:16][C:17]([OH:19])=[O:18])[CH:6]=[CH:5][N:4]=[CH:3]1

Participants

3

Reactant 1

HCID 13569176HCID 13569176, compound

Product 1

HCID 13569190HCID 13569190, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of ethyl 2-[2-(1-imidazolyl)ethoxy]phenylacetate hydrochloride (3.5 g) in 5N hydrochloric acid (20 ml) was heated on a steam bath for 6 hours and then evaporated. The residue was crystallised from isopropanol to give 2-[2-(1-imidazolyl)ethoxy]phenylacetic acid hydrochloride, m.p. 146°-147°. Found: C, 54.69; H, 5.25; N, 9.80. C15H14N2O3.HCl requires: C, 55.22; H, 5.35; N, 9.91%.

Workup

  1. customevaporated
  2. customThe residue was crystallised from isopropanol

Sources & evidence

ORD record
ord-4490006050984b6f957b11207b9fc394
Source dataset
uspto-grants-1987_01
Patent number
US04636500

Reaction notes

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