反应详情

17 g of N-(2-((2-hydroxy-3-(4-hydroxyphenoxy)propyl)amino)ethyl)-4-morpholinecarboxamide and 6 g of 2-methoxyethyl mesylate and 6.9 g of K2CO3 was refluxed in acetonitril for 20 h. The resulting mixture was filtered and evaporated. The residue was dissolved in methylene chloride and extracted with water containing 1 g of NaOH, then with water and then dried over Na2SO4, filtered and evaporated. The residue was crystallized from ethyl acetate yielding N-(2-((2-hydroxy-3-(4-(2-methoxyethoxy)phenoxy)propyl)amino)ethyl)-4-morpholinecarboxamide. Melting point 69° C. (base).

1. filtrationThe resulting mixture was filtered
2. customevaporated
3. dissolutionThe residue was dissolved in methylene chloride
4. extractionextracted with water containing 1 g of NaOH
5. dry with materialwith water and then dried over Na2SO4
6. filtrationfiltered
7. customevaporated
8. customThe residue was crystallized from ethyl acetate