2-Bromo-4'-nitroacetophenone → HCID 12795541, compound

HRID 980173Notes

Reaction equation

HRID 980173 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[NH:6][CH:7]=1.Br[CH2:10][C:11]([C:13]1[CH:18]=[CH:17][C:16]([N+:19]([O-:21])=[O:20])=[CH:15][CH:14]=1)=[O:12]>C(N(CC)CC)C.C(O)C.O>[Cl:1][C:2]1[CH:3]=[N:4][C:5](=[O:8])[N:6]([CH2:10][C:11]([C:13]2[CH:14]=[CH:15][C:16]([N+:19]([O-:21])=[O:20])=[CH:17][CH:18]=2)=[O:12])[CH:7]=1

Participants

6

Reactant 2

HCID 668402-Bromo-4'-nitroacetophenoneHCID 1085785-Chloro-2(1H)-pyrimidinone

Product 1

HCID 12795541HCID 12795541, compound

Reagents, catalysts & solvents 3

HCID 702EthanolSolventHCID 962WaterSolventHCID 8471TriethylamineSolvent

Procedure

A mixture of 5-chloropyrimidin-2-one (787 mg) and 2-bromo-4'-nitroacetophenone (1.47 g) in triethylamine (2 ml) and ethanol (40 ml) was stirred at ambient temperature for 1 hr. The reaction mixture was diluted with water and the solid filtered off.

Workup

  1. filtrationthe solid filtered off

Sources & evidence

ORD record
ord-62e172e0e99b4cab82ec565437da2c0a
Source dataset
uspto-grants-1987_01
Patent number
US04636509

Reaction notes

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