反应详情

2,3-Epoxypropyl-4-methoxybenzyl ether (100 g, 0.725M) in dry tetrahydrofuran (200 ml) was treated with imidazole (44.4 g, 0.765M) and heated under reflux for 16 hours. The solution was filtered and the solvent was evaporated off under reduced pressure to give a brown solid which was recrystallised from 10% water-propan-1-ol to give 1-[2-Hydroxy-3-[(4-methoxyphenyl)methoxy]propyl]-1H-imidazole (83 g) as a colourless crystalline solid, m.p. 96°-98° C.

1. temperatureheated
2. temperatureunder reflux for 16 hours
3. filtrationThe solution was filtered
4. customthe solvent was evaporated off under reduced pressure
5. customto give a brown solid which
6. customwas recrystallised from 10% water-propan-1-ol