Methyl iodide → HCID 12822485, compound

Participants

Reaction Steps

In a similar manner to that described in Example 10(i), N-[[3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-1H-indol-5-yl]methyl]-trifluoromethanesulphonamide (1.04 g), sodium hydride (80%, 0.72 g) and methyl iodide (0.6 ml) in dimethylformamide (15 ml) gave the title compound (0.51 g) as a yellow solid m.p. 131°-3° after column chromatography on kieselgel 60 (80 g) eluted with ether/cyclohexane (4:1).

Provenance & Evidence