Methyl iodide → HCID 12822485, compound

HRID 980298Notes

Reaction equation

HRID 980298 reaction equation
[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][NH:24][S:25]([C:28]([F:31])([F:30])[F:29])(=[O:27])=[O:26])[CH:21]=2)[NH:16][CH:15]=1.[H-].[Na+].[CH3:34]I>CN(C)C=O>[O:1]=[C:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4](=[O:11])[N:3]1[CH2:12][CH2:13][C:14]1[C:22]2[C:17](=[CH:18][CH:19]=[C:20]([CH2:23][N:24]([CH3:34])[S:25]([C:28]([F:30])([F:31])[F:29])(=[O:27])=[O:26])[CH:21]=2)[NH:16][CH:15]=1

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 12822476HCID 12822476, compound

Product 1

HCID 12822485HCID 12822485, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a similar manner to that described in Example 10(i), N-[[3-[2-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl]-1H-indol-5-yl]methyl]-trifluoromethanesulphonamide (1.04 g), sodium hydride (80%, 0.72 g) and methyl iodide (0.6 ml) in dimethylformamide (15 ml) gave the title compound (0.51 g) as a yellow solid m.p. 131°-3° after column chromatography on kieselgel 60 (80 g) eluted with ether/cyclohexane (4:1).

Sources & evidence

ORD record
ord-79c99626cea749ae8fceb8ae90a8572e
Source dataset
uspto-grants-1987_01
Patent number
US04636521

Reaction notes

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