2-Vinylquinoline → 8-Fluoro-2,3,4,5-tetrahydro-2-[2-(2-quinolinyl)ethyl]-1H-pyrido[4-3-b]indole

HRID 980313Notes

Reaction equation

HRID 980313 reaction equation
[CH:1]([C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[N:4]=1)=[CH2:2].[C:13]1(N)[C:18]([F:19])=[C:17](F)[C:16](F)=[C:15]([NH2:22])[C:14]=1F.Cl.Cl>>[F:19][C:18]1[CH:13]=[CH:14][C:15]2[NH:22][C:11]3[CH2:10][CH2:5][N:4]([CH2:2][CH2:1][C:3]4[CH:12]=[CH:11][C:10]5[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=5)[N:4]=4)[CH2:3][C:12]=3[C:16]=2[CH:17]=1

Participants

3

Reactant 2

HCID 698752-VinylquinolineHCID 149026Tetrafluoro-m-phenylenediamine dihydrochloride

Product 1

HCID 137724428-Fluoro-2,3,4,5-tetrahydro-2-[2-(2-quinolinyl)ethyl]-1H-pyrido[4-3-b]indole

Procedure

The title compound was prepared following the procedure of Example 2 with the exception that 2-vinylquinoline was used instead of 2-vinylpyridine. The product was converted to the dihydrochloride salt; mp 192°-194° C.

Sources & evidence

ORD record
ord-8ba977ed4d1f4935be9f92a95f034f28
Source dataset
uspto-grants-1987_01
Patent number
US04636563

Reaction notes

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