Hydrochloric Acid → HCID 13107023, compound

HRID 980334Notes

Reaction equation

HRID 980334 reaction equation
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.C(O)C.Cl.[N-:25]=[C:26]=[O:27].[K+]>O>[C:17]([C:8]1[CH:7]=[C:6]([C:4]2[NH:25][C:26](=[O:27])[NH:2][CH:3]=2)[CH:11]=[C:10]([C:12]([CH3:13])([CH3:15])[CH3:14])[C:9]=1[OH:16])([CH3:19])([CH3:20])[CH3:18]

Participants

6

Reactant 4

HCID 313Hydrochloric Acid2×HCID 702EthanolHCID 11051572Potassio isocyanateHCID 20222368HCID 20222368, compound

Product 1

HCID 13107023HCID 13107023, compoundYield 43.3%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

To a mixed solution of 1.2 g of 4-(2-aminoacetyl)-2,6-di-tert-butylphenol hydrochloride, 10 ml of ethanol, and 0.3 ml of concentrated hydrochloric acid was added a solution of 0.64 g of potassium isocyanate in 3 ml of water at room temperature. After stirring the mixture for 2 hours, 0.3 ml of concentrated hydrochloric acid was added thereto and the resultant mixture was refluxed for 2 hours. The reaction mixture thus obtained was poured into water and the precipitates formed were recovered by filtration. The reaction product was then recrystallized from aqueous ethanol to provide 0.5 g of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-2-oxo-4-imidazoline.

Workup

  1. customThe reaction mixture thus obtained
  2. customthe precipitates formed
  3. filtrationwere recovered by filtration
  4. customThe reaction product was then recrystallized from aqueous ethanol

Sources & evidence

ORD record
ord-e93a537332494027bb08aa1ab3f07866
Source dataset
uspto-grants-1987_01
Patent number
US04636516

Reaction notes

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