Hydrochloric Acid → HCID 13107024, compound

HRID 980335Notes

Reaction equation

HRID 980335 reaction equation
Cl.[NH2:2][CH:3]([CH3:22])[C:4]([C:6]1(O)[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH2:7]1)=O.Cl.[N-:24]=[C:25]=[O:26].[K+]>C(O)C>[C:17]([C:8]1[CH:7]=[C:6]([C:4]2[NH:24][C:25](=[O:26])[NH:2][C:3]=2[CH3:22])[CH:11]=[C:10]([C:12]([CH3:14])([CH3:15])[CH3:13])[C:9]=1[OH:16])([CH3:20])([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 11051572Potassio isocyanateHCID 70445001HCID 70445001, compound

Product 1

HCID 13107024HCID 13107024, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

By following the same procedure as in Example 6 using 1.6 g of 4-(2-aminopropionyl)-2,6-di-tert-butyl-4-hydroxyphenol hydrochloride, 20 ml of ethanol, 0.5 ml of concentrated hydrochloric acid, 0.8 g of potassium isocyanate, a reaction product thus obtained was recrystallized from aqueous isopropanol to provide 0.7 g of 4-(3.5-di-tert-butyl-4-hydroxyphenyl)-5-methyl-2-oxo-4-imidazoline.

Workup

  1. customa reaction product thus obtained
  2. customwas recrystallized from aqueous isopropanol

Sources & evidence

ORD record
ord-d71554b679be42abbabaaa435c9447a0
Source dataset
uspto-grants-1987_01
Patent number
US04636516

Reaction notes

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