Hydrochloric Acid → HCID 13107036, compound

HRID 980344Notes

Reaction equation

HRID 980344 reaction equation
Cl.[NH2:2][CH:3]([CH2:21][CH3:22])[C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.[N-:23]=[C:24]=[O:25].[K+].Cl>>[C:12]([C:10]1[CH:11]=[C:6]([C:4]2[NH:23][C:24](=[O:25])[NH:2][C:3]=2[CH2:21][CH3:22])[CH:7]=[C:8]([C:17]([CH3:19])([CH3:18])[CH3:20])[C:9]=1[OH:16])([CH3:14])([CH3:13])[CH3:15]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 11051572Potassio isocyanateHCID 20222370HCID 20222370, compound

Product 1

HCID 13107036HCID 13107036, compoundYield 50.2%

Procedure

By following the same procedure as in Example 6 using 3.3 g of 2-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-1-butanone hydrochloride, 1.62 g of potassium isocyanate, and 1.6 ml of concentrated hydrochloric acid and recrystallizing the reaction product from aqueous isopropanol, 1.6 g of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-ethyl-2-oxo-4-imidazoline was obtained.

Workup

  1. customrecrystallizing the reaction product from aqueous isopropanol

Sources & evidence

ORD record
ord-d3633741edc6440ab3e95351d9903f09
Source dataset
uspto-grants-1987_01
Patent number
US04636516

Reaction notes

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