Hydrochloric Acid → HCID 13107039, compound

HRID 980347Notes

Reaction equation

HRID 980347 reaction equation
Cl.[NH2:2][CH:3]([CH:21]([CH3:23])[CH3:22])[C:4]([C:6]1[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]([OH:16])=[C:8]([C:17]([CH3:20])([CH3:19])[CH3:18])[CH:7]=1)=O.[S-:24][C:25]#[N:26].[Na+].Cl>C(O)(=O)C>[C:17]([C:8]1[CH:7]=[C:6]([C:4]2[NH:26][C:25](=[S:24])[NH:2][C:3]=2[CH:21]([CH3:23])[CH3:22])[CH:11]=[C:10]([C:12]([CH3:15])([CH3:14])[CH3:13])[C:9]=1[OH:16])([CH3:20])([CH3:19])[CH3:18]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 516871Sodium thiocyanateHCID 20222373HCID 20222373, compound

Product 1

HCID 13107039HCID 13107039, compoundYield 23.2%

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

By following the same procedure as in Example 8 using 3.4 g of 2-amino-1-(3,5-di-tert-butyl-4-hydroxyphenyl)-3-methyl-1-butanone hydrochloride, 1.6 g of sodium thiocyanate, 1 ml of concentrated hydrochloric acid, and 31 ml of acetic acid and recrystallizing the reaction product from water-containing isopropanol, 0.8 g of 4-(3,5-di-tert-butyl-4-hydroxyphenyl)-5-isopropyl-2-thioxo-4-imidazoline was obtained.

Workup

  1. customrecrystallizing the reaction product from water-
  2. additioncontaining isopropanol

Sources & evidence

ORD record
ord-3c3a8a86d9464524a87ea858aa4bd2e3
Source dataset
uspto-grants-1987_01
Patent number
US04636516

Reaction notes

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