反应详情

温度

-10 °C

0.432 mol (75 g) of 3-chloro-4-nitrophenol is introduced into 282 ml of ethylenediamine and the reaction mixture is heated on a boiling waterbath for 13 hours. The cooled solution is then poured into 2.6 liters of ice-water to which 1.09 liters of hydrochloric acid (d=1.18) have been added. After the mixture has been cooled to -10° C. for a few hours, 3-β-aminoethylamino-4-nitrophenol hydrochloride crystallises. It is filtered off with suction and washed with an ice-cold 2N hydrochloric acid solution and then with ethanol. After recrystallisation from water, the dried product melts, with decomposition, at a temperature above 260° C.

1. temperaturethe reaction mixture is heated on a boiling waterbath for 13 hours
2. additionhave been added
3. custom3-β-aminoethylamino-4-nitrophenol hydrochloride crystallises
4. filtrationIt is filtered off with suction
5. washwashed with an ice-cold 2N hydrochloric acid solution
6. customAfter recrystallisation from water
7. customat a temperature above 260° C.