Thionyl Chloride → HCID 178444488, compound

HRID 980424Notes

Reaction equation

HRID 980424 reaction equation
[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([CH2:12][C:13]([OH:15])=O)[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5].S(Cl)([Cl:18])=O>>[CH2:1]([C@H:6]1[CH2:11][CH2:10][C@H:9]([CH2:12][C:13]([Cl:18])=[O:15])[CH2:8][CH2:7]1)[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

3

Reactant 2

HCID 24386Thionyl ChlorideHCID 178444491HCID 178444491, compound

Product 1

HCID 178444488HCID 178444488, compound

Procedure

For conversion into the acid chloride, trans-4-pentylcyclohexylacetic acid (12.0 g, 0.0566 mol) was reacted for about 1 hour on an oil bath at 80° C. with thionyl chloride (50 ml). The solution obtained was evaporated under reduced pressure, treated with absolute toluene (50 ml) and once more evaporated under reduced pressure.

Workup

  1. customThe solution obtained
  2. customwas evaporated under reduced pressure
  3. additiontreated with absolute toluene (50 ml)
  4. customonce more evaporated under reduced pressure

Sources & evidence

ORD record
ord-f5c682759cb14903a7140f0f7b826a0a
Source dataset
uspto-grants-1987_01
Patent number
US04637897

Reaction notes

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