Potassium Hydroxide → 5-Bromosalicylhydroxamic acid

HRID 980427Notes

Reaction equation

HRID 980427 reaction equation
[OH-:1].[K+].[Br:3][C:4]1[CH:18]=[C:8]([C:9](OC2C=CC=CC=2)=[O:10])[C:7]([OH:19])=[CH:6][CH:5]=1.Cl.[NH2:21]O>CO>[Br:3][C:4]1[CH:18]=[C:8]([C:9]([NH:21][OH:1])=[O:10])[C:7]([OH:19])=[CH:6][CH:5]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 266984Phenyl 5-bromo-2-hydroxybenzoate2×HCID 443297Hydroxyamine hydrochloride

Product 1

HCID 220465-Bromosalicylhydroxamic acid

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Procedure

A methanol solution of 127 g of KOH was gradually added to a methanol solution of 210 g of phenyl 5-bromosalicylate prepared as in (2-1) above and 105 g of hydroxylamine hydrochloride. After stirring for 4 hours, the precipitate formed was collected by filtration. The precipitation was then suspended in water, and 60 ml of conc. hydrochloric acid (35%) was added thereto, followed by stirring for two hours to collect the precipitate by filtration followed by drying. Yield: 136 g.

Workup

  1. customthe precipitate formed
  2. filtrationwas collected by filtration
  3. customThe precipitation
  4. addition60 ml of conc. hydrochloric acid (35%) was added
  5. stirringby stirring for two hours
  6. customto collect the precipitate
  7. filtrationby filtration
  8. customby drying

Sources & evidence

ORD record
ord-b221f47e46fb4456a9cee6c90c3f2d22
Source dataset
uspto-grants-1987_01
Patent number
US04637902

Reaction notes

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