Potassium Carbonate → HCID 54419620, compound

HRID 980436Notes

Reaction equation

HRID 980436 reaction equation
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([NH2:17])(=[O:16])=[O:15].Cl[CH2:19][CH:20]=[N:21][O:22][CH3:23]>C(#N)C>[CH3:23][O:22][N:21]=[CH:20][CH2:19][O:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[S:14]([NH2:17])(=[O:15])=[O:16]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 6375462-Hydroxybenzene-1-sulfonamideHCID 54132102HCID 54132102, compound

Product 1

HCID 54419620HCID 54419620, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

30 g (0.2 mol) of potassium carbonate are introduced into a stirred solution of 18 g (0.1 mol) of 2-hydroxybenzenesulphonamide in 20 ml of acetonitrile. 11 g (0.1 mol) of 1-chloro-2-methoxyiminoethane are then rapidly added dropwise, and the mixture is heated at the boiling point for a further 3 hours. The precipitate which separates out is filtered off under suction, in filtrate is evaporated down, the oily residue is triturated with water, and the product is filtered off under suction and dried on clay. 14 g (57% of theory) of 2-(2-methoxyiminoethoxy)phenylsulphonamide of melting point 103° to 105° C. are obtained.

Workup

  1. temperaturethe mixture is heated at the boiling point for a further 3 hours
  2. filtrationThe precipitate which separates out is filtered off under suction, in filtrate
  3. customis evaporated down
  4. customthe oily residue is triturated with water
  5. filtrationthe product is filtered off under suction
  6. customdried on clay

Sources & evidence

ORD record
ord-b65c0f32ad8e40a69affe678d6caf7c5
Source dataset
uspto-grants-1987_01
Patent number
US04638004

Reaction notes

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